“Spring is the time of plans and projects.”
Anna Karenina

Time for our spring update:

Hot off the pressesOn the ten year anniversary of his groundbreaking IL7R paper, our Principal Investigator Dr. Simon Gregory has published another exciting report. It describes how the gene DDX39B regulates IL7R and establishes that genetic variants in DDX39B also increase risk for developing MS. This reveals an important new functional pathway implicated in the development of not only MS, but also other autoimmune diseases such as rheumatoid arthritis and juvenile diabetes. A team of scientists from Duke, UT Medical Branch, UC Berkeley, and Case Western Reserve produced this important work, which used samples from MURDOCK Study participants and was funded in part by Herman Stone and family. Big thanks and congratulations to all.

Tales from the bench. We’ve completed some important ‘omic datasets from our MURDOCK Study samples. We have metabolomic, genotype, and gene expression profiles for a core set of individuals. Now it’s a matter of analyzing them together to identify clues about how genetic risk for MS relates to gene expression and changes in metabolism.

Get involved. Saturday May 6th Team Discovery MS will be walking in the Kannapolis, NC National MS Society Walk. Join us!

Collaborator shoutout. Congratulations to our collaborator Dr. Farren Briggs for his paper investigating how smoking affects the quality of life and disability accrual of people with MS. Also, Dr. Mari Shinohara published a review on inflammation in MS and a mouse MS model. Good reads!

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